In Situ Gelling Gelrite/Alginate Formulations as Vehicles for Ophthalmic Drug Delivery

in situ gelling systems for drug delivery

In Situ Gelling Systems for Drug Delivery

Implication for health policy/practice/research/medical education: Development of polymeric in situ gels for controlled release of various drugs provides a number of advantages over conventional dosage forms. Some important advantages of these smart systems are ease of application and reduced frequency of administration, as well as protection of the drug from environmental conditions. Published...

Ion-activated In Situ Gelling Ophthalmic Delivery Systems of Azithromycin

Gelation of pectin caused by divalent cations especially calcium ions has been applied to develop an ophthalmic formulation of azithromycin in the present study. Rapid elimination of drug on instillation into cul de sac would be minimal with in situ gelling ophthalmic solution leading to increased precorneal contact time and prolonged drug delivery. In the formulation development studies pectin...

Development of a Novel Floating In-situ Gelling System for Stomach Specific Drug Delivery of the Narrow Absorption Window Drug Baclofen

The present study deals with development of a floating in-situ gel of the narrow absorption window drug baclofen. Sodium alginate-based in-situ gelling systems were prepared by dissolving various concentrations of sodium alginate in deionized water, to which varying concentrations of drug and calcium bicarbonate were added. Fourier transform infrared spectroscopy (FTIR) and differential scannin...

Development of a Novel Floating In-situ Gelling System for Stomach Specific Drug Delivery of the Narrow Absorption Window Drug Baclofen

The present study deals with development of a floating in-situ gel of the narrow absorption window drug baclofen. Sodium alginate-based in-situ gelling systems were prepared by dissolving various concentrations of sodium alginate in deionized water, to which varying concentrations of drug and calcium bicarbonate were added. Fourier transform infrared spectroscopy (FTIR) and differential scannin...